منابع مشابه
Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma
Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads re...
متن کاملPodoplanin discovery, structure and expression regulation 3. Podoplanin and lymphatic vessel development 4. Podoplanin and tumor metastasis facilitated by thrombus formation 5. Podoplanin and cancer cell migration, invasion and progression 6. Podoplanin expression in cells of normal and cancerous stroma
Cancer-associated fibroblasts (CAFs) are well-known to be part of the tumor microenvironment. This heterogeneous population of cells of the tumor microenvironment via secretion of various growth factors and cytokines was shown to contribute to increased cancer cell proliferation rate, migration, invasiveness and other key processes such as angiogenesis and lymphangiogenesis. Recent studies iden...
متن کاملLow Expression of Occludin in the Melanoma Patient
Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in cancer, the prognostic signific...
متن کاملComparative Aspects of Canine Melanoma
Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and mole...
متن کامل[Expression of podoplanin in ovarian clear cell carcinoma].
INTRODUCTION Podoplanin is a transmembrane glycoprotein expressed in endothelial lymphatic cells. It was proven to be a predictive marker in a variety of cancers e.g. mesothelioma and head and neck squamous-cell carcinoma. Ovarian clear cell carcinoma (OCCC) is a rare and unique histopathologic subtype of epithelial ovarian cancer (EOC). The molecular basis of that phenomenon remains unknown. ...
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ژورنال
عنوان ژورنال: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
سال: 2016
ISSN: 2167-9436
DOI: 10.1089/mab.2016.0040